CRISPR-Cas: an adaptive immunity system in prokaryotes
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چکیده
منابع مشابه
CRISPR-Cas: an adaptive immunity system in prokaryotes
Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity to mobile genetic elements known as the CRISPR (clustered regularly interspaced short palindromic repeats)-associated system (CRISPR-Cas), which consists of arrays of short repeats interspersed with unique DNA spacers and adjacent operons encompassing CRISPR-associated (cas) genes with predicted and, in s...
متن کاملCRISPR-Cas: the effective immune systems in the prokaryotes
Approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an RNAi-like pathway. CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems consist of the CRISPR loci with multiple copies of a short repeat sequence separa...
متن کاملEvolutionary dynamics of the prokaryotic adaptive immunity system CRISPR-Cas in an explicit ecological context.
A stochastic, agent-based mathematical model of the coevolution of the archaeal and bacterial adaptive immunity system, CRISPR-Cas, and lytic viruses shows that CRISPR-Cas immunity can stabilize the virus-host coexistence rather than leading to the extinction of the virus. In the model, CRISPR-Cas immunity does not specifically promote viral diversity, presumably because the selection pressure ...
متن کاملcrispr-cas: the effective immune systems in the prokaryotes
approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an rnai-like pathway. crispr–cas (clustered regularly interspaced short palindromic repeats–crispr-associated proteins) systems consist of the crispr loci with multiple copies of a short repeat sequence separa...
متن کاملCRISPR-Cas adaptive immunity and the three Rs
In this summary, we focus on fundamental biology of Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)-Cas (CRISPR-associated proteins) adaptive immunity in bacteria. Emphasis is placed on emerging information about functional interplay between Cas proteins and proteins that remodel DNA during homologous recombination (HR), DNA replication or DNA repair. We highlight how replic...
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ژورنال
عنوان ژورنال: F1000 Biology Reports
سال: 2009
ISSN: 1757-594X
DOI: 10.3410/b1-95